Hyper-IgE in the allergy clinic--when is it primary immunodeficiency?
نویسندگان
چکیده
منابع مشابه
Is It Hyper IgE Syndrome Or Something Else?
Elevated IgE levels can be associated with a variety of causes. The diagnosis is most often made on a clinical basis taking into consideration a complete history and physical. In this case report we describe a patient with elevated IgE levels and our discovery upon further investigation after noticing some unique findings on his physical examination. The differential diagnosis of extremely elev...
متن کاملDefects in Jak-STAT-mediated cytokine signals cause hyper-IgE syndrome: lessons from a primary immunodeficiency.
Hyper-IgE syndrome (HIES) is a primary immunodeficiency characterized by atopic manifestations and susceptibility to infections with extracellular bacteria and fungi, which frequently occur in the skin and lung. Atopic manifestations in HIES include extremely high serum IgE levels, eczema and eosinophilia. Most of the extracellular bacterial infections are associated with disproportionally mild...
متن کاملمعرفی یک مورد سندرم ازدیاد Hyper-IgE Syndrome) IgE)
Hyper IgE syndrome (Job’s syndrome) is a primary immunodeficiency disease with recurrent infections especially staphylococcal, coarse face, skeletal abnormality and significant increase in serum IgE level (IgE >2000IU/ml). We present a 16 years old boy admitted with chronic cough, dyspnea, eczema and pneumatocele. He had a history of chronic dermal infection since 1 month after birth. The dia...
متن کاملگزارش تظاهرات ریوی در سندرم Hyper IgE
سابقه و هدف: سندرم Hyper IgE بیماری نادری از دسته سندرم‌های کمبود ایمنی اولیه است که با مشخصات عفونت‌های ریوی و جلدی، اگزما و افزایش سطح سرمی IgE مشخص می‌شود. در این مقاله، 4 بیمار مبتلا به عفونت‌های متعدد ریوی در زمینه سندرم Hyper IgE. معرفی می‌گردند. معرفی مورد: در این مطالعه 4 دختر که سابقه عفونت‌های ریوی متعدد داشتند، بررسی شدند و در نهایت سندرم Hyper IgE در آنها تشخیص داده شد. در تمامی ...
متن کاملWhen less is more: primary immunodeficiency with an autoinflammatory kick
PURPOSE OF REVIEW Next-generation sequencing is revolutionizing the molecular taxonomy of human disease. Recent studies of patients with unexplained autoinflammatory disorders reveal germline genetic mutations that target important regulators of innate immunity. RECENT FINDINGS Whole-exome analyses of previously undiagnosed patients have catalyzed the recognition of two new disease genes. Fir...
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ژورنال
عنوان ژورنال: Allergy
سال: 2018
ISSN: 0105-4538
DOI: 10.1111/all.13578